Docking and Quantitative Structure Activity Relationship studies of Acyl Guanidines as β-Secretase (BACE1) Inhibitor
نویسندگان
چکیده
منابع مشابه
quantitative structure activity relationship and docking studies on imidazole derivatives as p-glycoprotein inhibitors
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Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
Beta-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for its role in Alzheimer's disease as the beta-secretase responsible for generating the amyloid-beta protein. Emerging evidence from mouse models has identified the importanc...
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ژورنال
عنوان ژورنال: Bulletin of the Korean Chemical Society
سال: 2014
ISSN: 0253-2964
DOI: 10.5012/bkcs.2014.35.7.2065